To ensure accurate chromosome segregation during mitosis, the spindle checkpoint monitors chromosome alignment on the mitotic spindle. Indjeian and colleagues have investigated the precise role of the shugoshin 1 protein (Sgo1p) in this process in budding yeast.1 The Sgo proteins were originally identified as highly conserved proteins that protect cohesion at centromeres during the first meiotic division. Together with other recent findings,2 the study highlighted here has identified Sgo1 as a component that informs the mitotic spindle checkpoint when spindle tension (...) is perturbed. This discovery has provided a molecular link between sister chromatid cohesion and tension‐sensing at the kinetochore–microtubule interface. BioEssays 27:588–591, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

A representationalist-friendly introduction to representationalism which covers a number of central problems and objections.

What the Church teaches and why on issues of euthanasia, invitro fertilization, genetic counseling, assisted suicide, living wills, persistent vegetative state, organ transplants, and more.

In this foundational work in contemporary political theory, William Connolly makes a distinctive contribution to our understanding of the relationship between ...

To say that God is sovereign over all things is to say that everything depends on God. To say that God exists a se is to say that Gods depends on nothing. This chapter examines and defends strong versions of five theses pertaining to God’s sovereignty and aseity: Everything that exists depends on God for its existence. Every situation that is the case depends on God for its being the case.God depends on nothing for his existence. God depends on nothing (...) for his being what he is.God is perfectly free. The implications of these theses for the doctrines of creation ex nihilo, continuous creation, and God’s eternality, freedom, and simplicity are discussed. I argue that although the theses portray a deity who is quite different from humans, they nevertheless are consistent with God’s being personal, that is, a being to whom beliefs, desires, intentions, and emotions are correctly ascribed. (shrink)

The foundation of the Christian counselling movement -- Christian counselling in the UK -- The aims of Christian counselling -- Integrating psychological and biblical truth -- Sigmund Freud--the founding father of psychotherapy -- The individual psychology of Alfred Adler -- Abraham Maslow--the man with new age tendencies -- Carl Rogers--a man who believed in himself -- Albert Ellis--the aggressive atheist -- The Bible's verdict on psychological 'truth' -- The case against Larry Crabb -- Self-esteem: the secular foundation -- Self-esteem and (...) the Christian counselling movement -- Self-esteem dogma in the light of scripture. (shrink)

But in Why I Am Not a Secularist, distinguished political theorist William E. Connolly argues that secularism, although admirable in its pursuit of freedom and diversity, too often undercuts these goals through its narrow and intolerant ...

Complexity, agency, and time -- The vicissitudes of experience -- Belief, spirituality, and time -- The human predicament -- Capital flows, sovereign decisions, and world resonance machines -- The theorist and the seer.

This article offers a fresh assessment of the views of the American paleontologist and evolutionary biologist Stephen Jay Gould on the relation of science and religion. Gould is best known for his celebrated notion of “nonoverlapping magisteria,” which is often seen in somewhat negative terms as inhibiting dialogue. However, as a result of his critique of the unificationist approach to knowledge developed in Edward O. Wilson's Consilience, Gould later made increased use of the more positive notion of (...) a “consilience of equal regard,” which recognized the porous nature of disciplinary divides and the propriety of interdisciplinary dialogue. Gould's final views on the relation of science and religion, set out in The Hedgehog, the Fox, and the Magister's Pox, published after his death, affirms the distinctiveness and autonomy of science and religion on the one hand, while encouraging their constructive dialogue and productive interaction on the other. This should now be seen as Gould's definitive statement on this question. (shrink)